Add like
Add dislike
Add to saved papers

[Molecular Diagnosis and Treatment of HBOC Syndrome].

Hereditary breast and ovarian cancer(HBOC)is an inherited cancer caused by mutations of the BRCA1 or BRCA2 genes. BRCA genetic testing is used for HBOC diagnosis and continues to progress such as the annotation of VUS. In HBOC clinical practice, surveillance methods have been established through collaboration between genetic medicine and cancer medicine, and treatment, including options based on genetic diagnosis, has advanced significantly. Furthermore, the analysis of BRCA1 and BRCA2 function has progressed, and a novel therapeutic method based on synthetic lethality, such as a PARP inhibitor use, has been developed. Furthermore, BRCA genetic testing is going to be used as a PGx test for the selection of sensitive cases. Meanwhile, familial breast cancer and ovarian cancer, in which cases of breast and ovarian cancer accumulate in the family, vary from some patients carrying a single mutated gene, such as BRCA1, to families that have multifactorial predisposing causes. Responsible genes of each group have been identified as high, moderate, and low susceptibility genes, and there are a number of cases where the responsible genes are unknown. Such genes need to be identified and a new diagnostic system needs to be established.

Full text links

We have located links that may give you full text access.
Can't access the paper?
Try logging in through your university/institutional subscription. For a smoother one-click institutional access experience, please use our mobile app.

For the best experience, use the Read mobile app

Mobile app image

Get seemless 1-tap access through your institution/university

For the best experience, use the Read mobile app

All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.

By using this service, you agree to our terms of use and privacy policy.

Your Privacy Choices Toggle icon

You can now claim free CME credits for this literature searchClaim now

Get seemless 1-tap access through your institution/university

For the best experience, use the Read mobile app