We have located links that may give you full text access.
JOURNAL ARTICLE
RESEARCH SUPPORT, NON-U.S. GOV'T
Antimalarial solid self-emulsifying system for oral use: in vitro investigation.
Therapeutic Delivery 2017 April
AIM: The low aqueous solubility of artemether and lumefantrine makes them less bioavailable. It is expected that by formulating self-microemulsifying drug-delivery systems (SMEDDS), their aqueous solubility and absorption will thus be enhanced. Results & methodology: Optimized liquid SMEDDS containing artemether and lumefantrine was adsorbed on Neusilin US2® employing spray drying technique to convert it into solid SMEDDS. Almost 90% of both drugs were released within 15 min in their respective official dissolution media. Drug assay and dissolution rate of solid SMEDDS remained unaltered after 3-month storage at 40°C and 75% relative humidity.
CONCLUSION: Reconstitution of solid SMEDDS in water yielded microemulsion with a globule size of 67.74 nm. Complete and faster in vitro release of both drugs from solid SMEDDS was observed as compared with that from marketed tablets.
CONCLUSION: Reconstitution of solid SMEDDS in water yielded microemulsion with a globule size of 67.74 nm. Complete and faster in vitro release of both drugs from solid SMEDDS was observed as compared with that from marketed tablets.
Full text links
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app