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Journal Article
Research Support, Non-U.S. Gov't
Expanding the genetic code of Mus musculus.
Nature Communications 2017 Februrary 22
Here we report the expansion of the genetic code of Mus musculus with various unnatural amino acids including Nɛ -acetyl-lysine. Stable integration of transgenes encoding an engineered Nɛ -acetyl-lysyl-tRNA synthetase (AcKRS)/tRNAPyl pair into the mouse genome enables site-specific incorporation of unnatural amino acids into a target protein in response to the amber codon. We demonstrate temporal and spatial control of protein acetylation in various organs of the transgenic mouse using a recombinant green fluorescent protein (GFPuv) as a model protein. This strategy will provide a powerful tool for systematic in vivo study of cellular proteins in the most commonly used mammalian model organism for human physiology and disease.
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