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JOURNAL ARTICLE
RESEARCH SUPPORT, N.I.H., EXTRAMURAL
RESEARCH SUPPORT, NON-U.S. GOV'T
REVIEW
Calcium Channels in Vascular Smooth Muscle.
Calcium (Ca2+ ) plays a central role in excitation, contraction, transcription, and proliferation of vascular smooth muscle cells (VSMs). Precise regulation of intracellular Ca2+ concentration ([Ca2+ ]i ) is crucial for proper physiological VSM function. Studies over the last several decades have revealed that VSMs express a variety of Ca2+ -permeable channels that orchestrate a dynamic, yet finely tuned regulation of [Ca2+ ]i . In this review, we discuss the major Ca2+ -permeable channels expressed in VSM and their contribution to vascular physiology and pathology.
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