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Characteristics of Myosin V Processivity.
IEEE/ACM Transactions on Computational Biology and Bioinformatics 2017 Februrary 15
Myosin V is a processive doubled-headed biomolecular motor involved in many intracellular organelle and vesicle transport. The unidirectional movement is coupled with the adenosine triphosphate (ATP) hydrolysis and product release cycle. With the progress of experimental techniques and the enhancement of measuring directness, detailed knowledge of the motility of myosin V has been obtained.Following the ATPase cycle, the 4-state mechanochemical model of the myosin V's processive movement is used. The transitions between various states take place in a stochastic manner. We can use the master equation to analyze and calculate quantitatively. Meanwhile the effect of the reverse reaction is takenfully into account. We fit the mean velocity, the mean dwell time, the mean run length andtheratio of forward/backward steps as a functionof ATP, ADP and Pi concertration. The theoretical curves are generally in line with the experimental data. This work provides a new insight for the characteristic of myosin V.
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