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Singling Out Chromosome Gains in Tumor Evolution.

Ryan M Naylor, Jan M van Deursen
Cancer Cell 2017 Februrary 14
In this issue of Cancer Cell, Sheltzer et al. shed new light on Theodor Boveri's century-old hypothesis by demonstrating that aneuploidy characterized by single-chromosome gains acts to suppress tumorigenesis and that aneuploidy itself is a nidus for genomic instability.

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