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Glutathione-responsive paclitaxel dimer nanovesicles with high drug content.

Qing Pei, Xiuli Hu, Junli Zhou, Shi Liu, Zhigang Xie
Biomaterials Science 2017 July 26
Paclitaxel dimer-based nanovesicles, with an ultrahigh drug content, have been prepared through a nanoprecipitation method. The as-formed nanovesicles exhibit improved paclitaxel solubility, prominent colloid stability, GSH-triggered disassembly, effective cellular uptake and comparable cytotoxicity to Taxol.

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