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Langerhans Cells: the 'Yin and Yang' of HIV Restriction and Transmission.
Trends in Microbiology 2017 March
Langerhans cells are specialized sentinels present in the epidermis expressing Langerin, a specific C-type lectin receptor involved in HIV capture and destruction. Recently, the specific mechanism leading to this HIV restriction was discovered. Nevertheless, Langerhans cells can be infected and the way HIV escapes this restriction needs to be unraveled.
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