Serum BNP level expression of child patients suffering from ventricular septal defects of CHD and its relation with cardiac function and heart failure.

BACKGROUND: To explore BNP level expression of child patients suffering from ventricular septal defects of CHD and analyze the relationship between BNP and cardiac function and heart failure.

METHODS: To select 92 cases of child patients with ventricular septal defects of CHD in this hospital from Oct. 2012 to Sep. 2014, which were divided into no HF group (n=30), mild HF group (n=31) and moderate and severe HF group (n=31) based on the scoring standard of NYU PHFI. At meanwhile, 32 healthy children cases of the same period were taken as control group. Collect venous blood to test serum BNP level and left ventricular ejection fraction (LVEF), left ventricular ejection fraction shortening (LVFS), left ventricular end-diastolic dimension index (LVEDDI) and cardiac index (CI) of all children.

RESULTS: Serum BNP content and LVEDDI level of CHD child patients were obviously higher than those of the control group, while LVEF, LVFS and CI were significantly lower (P<0.05); with HF getting severer, BNP and LVEDDI levels increased while LVEF, LVFS and CI levels gradually went down (P<0.05); serum BNP content was negatively correlated to LVEF, LVFS and CI (r=-1.142, -1.171 and -1.156, P<0.05) while positively correlated to LVEDDI and HF (r=0.134 and 1.143, P<0.05).

CONCLUSIONS: Serum BNP content of the child patients suffering from ventricular septal defects of CHD was linear correlated to the cardiac function index while positively correlated to HF, which was really important in terms of diagnosis, treatment and prognosis of HF.