We have located links that may give you full text access.
Effect of Photodynamic Therapy on Optical Coherence Tomography Angiography in Eyes with Chronic Central Serous Chorioretinopathy.
PURPOSE: To analyze the use of optical coherence tomography angiography (OCTA) in order to observe the changes in chronic central serous chorioretinopathy (CCSC) after half-dose photodynamic therapy (PDT).
METHODS: This is a retrospective study evaluating an imaging technique in a cohort of patients. Fundus photography, fluorescein angiography (FA), indocyanine green angiography (ICGA) (Heidelberg Spectralis, Heidelberg, Germany), OCT, and OCTA with the split-spectrum amplitude-decorrelation angiography algorithm (XR Optovue, Fremont, CA, USA) were performed prior to half-dose PDT. OCT and OCTA were conducted at week 1, month 1, month 2, and month 3 after half-dose PDT.
RESULTS: A total of 33 eyes of 28 patients were enrolled in the study. At the baseline assessment, the patient pool had a mean best-correct visual acuity of logMAR 0.29 ± 0.34 and the mean choroidal thickness was 407.45 ± 77.98 µm. At month 3 after PDT, the patient pool had a mean best-correct visual acuity of logMAR 0.1 ± 0.17 and the mean choroidal thickness was 355.48 ± 67.90 µm. Abnormal flow in the choriocapillary, which corresponded to the initial examinations using OCTA, was observed in all 33 eyes (100%). The images show an irregular high pixel values interval from low pixel values. At week 1 after half-dose PDT, 25 eyes (75.8%) resembled the baseline images of the choriocapillary layer of OCTA. Areas of nonperfusion in the choriocapillary were observed in 5 eyes (15.2%), and vessel-like material in the choriocapillary was observed in 3 eyes (9.0%). At month 3 after PDT, the choriocapillary layer of OCTA was shown to return to normal in 32 eyes (97%).
CONCLUSIONS: We have detected choriocapillary changes in patients diagnosed with CCSC following half-dose PDT by using noninvasive OCTA. These findings provide new evidence in support of the previously proposed hypothesis on the effect of PDT and suggest that OCTA may become a useful tool in the follow-up of CCSC.
METHODS: This is a retrospective study evaluating an imaging technique in a cohort of patients. Fundus photography, fluorescein angiography (FA), indocyanine green angiography (ICGA) (Heidelberg Spectralis, Heidelberg, Germany), OCT, and OCTA with the split-spectrum amplitude-decorrelation angiography algorithm (XR Optovue, Fremont, CA, USA) were performed prior to half-dose PDT. OCT and OCTA were conducted at week 1, month 1, month 2, and month 3 after half-dose PDT.
RESULTS: A total of 33 eyes of 28 patients were enrolled in the study. At the baseline assessment, the patient pool had a mean best-correct visual acuity of logMAR 0.29 ± 0.34 and the mean choroidal thickness was 407.45 ± 77.98 µm. At month 3 after PDT, the patient pool had a mean best-correct visual acuity of logMAR 0.1 ± 0.17 and the mean choroidal thickness was 355.48 ± 67.90 µm. Abnormal flow in the choriocapillary, which corresponded to the initial examinations using OCTA, was observed in all 33 eyes (100%). The images show an irregular high pixel values interval from low pixel values. At week 1 after half-dose PDT, 25 eyes (75.8%) resembled the baseline images of the choriocapillary layer of OCTA. Areas of nonperfusion in the choriocapillary were observed in 5 eyes (15.2%), and vessel-like material in the choriocapillary was observed in 3 eyes (9.0%). At month 3 after PDT, the choriocapillary layer of OCTA was shown to return to normal in 32 eyes (97%).
CONCLUSIONS: We have detected choriocapillary changes in patients diagnosed with CCSC following half-dose PDT by using noninvasive OCTA. These findings provide new evidence in support of the previously proposed hypothesis on the effect of PDT and suggest that OCTA may become a useful tool in the follow-up of CCSC.
Full text links
Related Resources
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app