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Accelerated antidepressant response to lithium augmentation of imipramine.
Industrial Psychiatry Journal 2016 January
BACKGROUND: Treatment of depressive episode often poses a challenge. Although there are numerous medicines available for its treatment but they all have a lag period of 2-3 weeks before they start showing their result.
AIM: The aim of the present study was to test the hypothesis that an initial lithium-tricyclic antidepressant (TCA) combination has a quicker and better antidepressant effect than standard TCA treatment in unipolar depression.
MATERIALS AND METHODS: Twenty unipolar depressed inpatients under lithium-TCA treatment were compared with twenty patients with similar diagnosis treated with TCA-placebo combination. The duration of the study was 4 weeks under double-blind conditions.
RESULTS: Initial lithium-TCA treatment reduced depressive symptoms significantly more than TCA alone. The difference was evident from 1(st) week onward and persisted at 4 weeks.
CONCLUSION: Lithium augmentation of TCA at the outset offers a strategy to reduce the lag period of antidepressant action. The choice can be made for those patients who are likely to benefit from long-term prophylaxis.
AIM: The aim of the present study was to test the hypothesis that an initial lithium-tricyclic antidepressant (TCA) combination has a quicker and better antidepressant effect than standard TCA treatment in unipolar depression.
MATERIALS AND METHODS: Twenty unipolar depressed inpatients under lithium-TCA treatment were compared with twenty patients with similar diagnosis treated with TCA-placebo combination. The duration of the study was 4 weeks under double-blind conditions.
RESULTS: Initial lithium-TCA treatment reduced depressive symptoms significantly more than TCA alone. The difference was evident from 1(st) week onward and persisted at 4 weeks.
CONCLUSION: Lithium augmentation of TCA at the outset offers a strategy to reduce the lag period of antidepressant action. The choice can be made for those patients who are likely to benefit from long-term prophylaxis.
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