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The small molecule JIB-04 disrupts O 2 binding in the Fe-dependent histone demethylase KDM4A/JMJD2A.

Barbara Cascella, Soon Goo Lee, Sukrit Singh, Joseph M Jez, Liviu M Mirica
Chemical Communications : Chem Comm 2017 Februrary 10
JIB-04, a specific inhibitor of the O2 -activating, Fe-dependent histone lysine demethylases, is revealed to disrupt the binding of O2 in KDM4A/JMJD2A through a continuous O2 -consumption assay, X-ray crystal structure data, and molecular docking.

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