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CPEB4 links the clock and the UPR to protect the liver.

Paul C Moore, Scott A Oakes
Nature Cell Biology 2017 January 32
Under misfolded protein stress, the endoplasmic reticulum (ER) activates the unfolded protein response (UPR) to restore homeostasis, or commits the cell to apoptosis. A study now uncovers how the UPR is governed by the circadian clock to adjust ER protein-folding capacity to metabolic demand and protect against liver damage.

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