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Finding host targets for HIV therapy.

C Kimberly Tsui, Amita Gupta, Michael C Bassik
Nature Genetics 2017 January 32
A CRISPR screen conducted in a CD4+ T cell leukemia line has identified host factors required for HIV infection but dispensable for cellular survival. The results highlight sulfation on the HIV co-receptor CCR5 and cellular aggregation as potential targets for therapeutic intervention.

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