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Journal Article
Research Support, N.I.H., Extramural
Characterization of β-d- N 4 -Hydroxycytidine as a Novel Inhibitor of Chikungunya Virus.
Antimicrobial Agents and Chemotherapy 2017 April
Chikungunya virus (CHIKV) represents a reemerging global threat to human health. Recent outbreaks across Asia, Europe, Africa, and the Caribbean have prompted renewed scientific interest in this mosquito-borne alphavirus. There are currently no vaccines against CHIKV, and treatment has been limited to nonspecific antiviral agents, with suboptimal outcomes. Herein, we have identified β-d- N 4 -hydroxycytidine (NHC) as a novel inhibitor of CHIKV. NHC behaves as a pyrimidine ribonucleoside and selectively inhibits CHIKV replication in cell culture.
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