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Tulbaghia violacea Harv. plant extract affects cell wall synthesis in Aspergillus flavus.
Journal of Applied Microbiology 2017 April
AIMS: This study investigates the effect that aqueous extracts of Tulbaghia violacea Harv. harbouring plant saponins, phenolics and tannins have on Aspergillus flavus β-(1,3) glucan and chitin synthesis.
METHODS AND RESULTS: Aspergillus flavus was treated with various subinhibitory concentrations of an aqueous T. violacea plant extract and the β-(1,3) glucan and chitin content was determined together with glucan synthase and chitin synthase production respectively.
CONCLUSIONS: The aqueous extract caused a significant decline (P < 0·05) in β-glucan production in A. flavus in a dose-dependent manner when compared to the untreated sample. Further investigations showed a decrease in β-glucan synthase production as the concentration of the plant extract was increased. A significant reduction in total chitin content corresponding to a decrease in chitin synthase production in the presence of the plant extract was also found.
SIGNIFICANCE AND IMPACT OF THE STUDY: The broad spectrum activity and the efficacy of aqueous T. violacea plant extract on both β-glucan and chitin synthesis may limit the potential of the fungus developing resistance towards it and therefore the extract is an ideal candidate for use as a potential antifungal agent.
METHODS AND RESULTS: Aspergillus flavus was treated with various subinhibitory concentrations of an aqueous T. violacea plant extract and the β-(1,3) glucan and chitin content was determined together with glucan synthase and chitin synthase production respectively.
CONCLUSIONS: The aqueous extract caused a significant decline (P < 0·05) in β-glucan production in A. flavus in a dose-dependent manner when compared to the untreated sample. Further investigations showed a decrease in β-glucan synthase production as the concentration of the plant extract was increased. A significant reduction in total chitin content corresponding to a decrease in chitin synthase production in the presence of the plant extract was also found.
SIGNIFICANCE AND IMPACT OF THE STUDY: The broad spectrum activity and the efficacy of aqueous T. violacea plant extract on both β-glucan and chitin synthesis may limit the potential of the fungus developing resistance towards it and therefore the extract is an ideal candidate for use as a potential antifungal agent.
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