Focused Ultrasound Help Realize High Spatio-temporal Brain Imaging? - A Concept on Acousto-electrophysiological Neuroimaging.

We present a concept for integrating focused ultrasound (FUS) with electrophysiological neuroimaging, in order to achieve high spatio-temporal brain imaging. This approach, acousto-electrophysiological neuroimaging, leverages on the spatial focality and noninvasiveness of FUS, may potentially lead to a noninvasive human brain imaging modality with high resolution in both space and time domain. Through ultrasound modulation, spatial selectivity is accomplished for high resolution electrophysiological neuroimaging. The ultrasound modulation induced frequency shifting may potentially lead to a room temperature MEG device.