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Radiosynthesis of no-carrier-added meta-[(124)I]iodobenzylguanidine for PET imaging of metastatic neuroblastoma.
Meta-iodobenzylguanidine (mIBG) has been radiolabelled at the no-carrier-added level with [(124)I] for a proof of concept study to assess the diagnostic accuracy of [(124)I]mIBG PET/CT in detecting metastatic deposits in patients diagnosed with metastatic neuroblastoma. Radiolabelling of mIBG was achieved via the iododesilylation reaction between [(124)I]sodium iodide and meta-trimethylsilylbenzylguanidine. [(124)I]mIBG was produced in 62-70 % radioiodide incorporation yield from [(124)I]sodium iodide. The average amount of formulated [(124)I]mIBG was 359 MBq (range 344-389 MBq) with an average specific radioactivity of 4.1 TBq μmol(-1) (range 1.8-5.9 TBq μmol(-1)) at end of synthesis.
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