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Choline-based imaging of prostate cancer with combined [(18)F] fluorocholine PET and (1)H MR spectroscopy by means of integrated PET/MRI.
Clinical Imaging 2017 March
PURPOSE: To evaluate integrated PET/MRI/(1)H MR spectroscopy in patients with prostate cancer.
SUBJECTS AND METHODS: Data analysis comprised calculations of correlations of standardized uptake values (SUVs) and ratios of (choline+creatine)/citrate as well as of single metabolite values and a logistic regression analysis of PET data and MR spectroscopy data in 22 patients.
RESULTS: SUVmean and integral values of choline correlated significantly in tumors. Logistic regression analysis demonstrated diagnostic superiority of PET over spectroscopy.
CONCLUSION: Simultaneous acquisition of PET and MR spectroscopy with integrated PET/MRI is feasible. Choline compounds and choline metabolism show a positive significant correlation.
SUBJECTS AND METHODS: Data analysis comprised calculations of correlations of standardized uptake values (SUVs) and ratios of (choline+creatine)/citrate as well as of single metabolite values and a logistic regression analysis of PET data and MR spectroscopy data in 22 patients.
RESULTS: SUVmean and integral values of choline correlated significantly in tumors. Logistic regression analysis demonstrated diagnostic superiority of PET over spectroscopy.
CONCLUSION: Simultaneous acquisition of PET and MR spectroscopy with integrated PET/MRI is feasible. Choline compounds and choline metabolism show a positive significant correlation.
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