Not All Esophageal Tumors Equal.

Although squamous cell carcinomas and adenocarcinomas of the esophagus differ histologically, they are often lumped together in clinical trials. Genomic analysis shows that the two cancers are molecularly distinct. Esophageal adenocarcinomas are more similar to stomach adenocarcinomas, whereas esophageal squamous cell carcinomas are closer to head and neck squamous cell carcinomas.