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PHF13: A new player involved in RNA polymerase II transcriptional regulation and co-transcriptional splicing.

Alisa Fuchs, Marcos Torroba, Sarah Kinkley
Transcription 2017 March 16
We recently identified PHF13 as an H3K4me2/3 chromatin reader and transcriptional co-regulator. We found that PHF13 interacts with RNAPIIS5P and PRC2 stabilizing their association with active and bivalent promoters. Furthermore, mass spectrometry analysis identified ∼50 spliceosomal proteins in PHF13s interactome. Here, we will discuss the potential role of PHF13 in RNAPII pausing and co-transcriptional splicing.

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