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AAZTA: An Ideal Chelating Agent for the Development of (44) Sc PET Imaging Agents.
Angewandte Chemie 2017 January 19
Unprecedented fast and efficient complexation of Sc(III) was demonstrated with the chelating agent AAZTA (AAZTA=1,4-bis(carboxymethyl)-6-[bis(carboxymethyl)]amino-6-methylperhydro-1,4-diazepine) under mild experimental conditions. The robustness of the (44) Sc(AAZTA)(-) chelate and conjugated biomolecules thereof is further shown by in vivo PET imaging in healthy and tumor mice models. The new results pave the way towards development of efficient Sc-based radiopharmaceuticals using the AAZTA chelator.
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