Polyphenols and Performance: A Systematic Review and Meta-Analysis.

BACKGROUND: Polyphenols exert physiological effects that may impact athletic performance. Polyphenols are antioxidants that have been noted to hinder training adaptations, yet conversely they stimulate stress-related cell signalling pathways that trigger mitochondrial biogenesis and influence vascular function.

OBJECTIVE: To determine the overall effect of polyphenols on human athletic performance.

METHODS: A search strategy was completed using MEDLINE, EMBASE, CINAHL, AMED and SPORTDiscus in April 2016. The studies were screened and independently reviewed by two researchers against predetermined criteria for eligibility. As a result of this screening, 14 studies were included for meta-analysis. Of these, the studied populations were predominately-trained males with an average intervention dose of 688 ± 478 mg·day-1 .

RESULTS: The pooled results demonstrate polyphenol supplementation for at least 7 days increases performance by 1.90% (95% CI 0.40-3.39). Sub-analysis of seven studies using quercetin identified a performance increase of 2.82% (95% CI 2.05-3.58). There were no adverse effects reported in the studies in relation to the intervention.

CONCLUSION: Overall the pooled results show that polyphenols, and of note quercetin, are viable supplements to improve performance in healthy individuals.