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Self-assembled 4-(1,2-diphenylbut-1-en-1-yl)aniline based nanoparticles: podophyllotoxin and aloin as building blocks.

Gaia Fumagalli, Michael S Christodoulou, Benedetta Riva, Inigo Revuelta, Cristina Marucci, Veronica Collico, Davide Prosperi, Sergio Riva, Dario Perdicchia, Ivan Bassanini, Aida García-Argáez, Lisa Dalla Via, Daniele Passarella
Organic & Biomolecular Chemistry 2017 Februrary 2
The ability of 4-(1,2-diphenylbut-1-en-1-yl)aniline as a self-assembly inducer is reported. The conjugation of this moiety with aloin or podophyllotoxin resulted in spherical nanoparticles that were characterized by Dynamic Light Scattering (DLS), Transmission Electron Microscopy (TEM) and NanoSight technology. A preliminary biological evaluation on two cancer cell lines is reported.

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