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Proteomic Study of Blood Serum in Coronary Atherosclerosis.

E M Stakhneva, I A Meshcheryakova, E A Demidov, K V Starostin, Yu I Ragino, S E Peltek, M I Voevoda
Bulletin of Experimental Biology and Medicine 2017 January
Changes in the blood serum proteins were assessed in men with coronary atherosclerosis and without coronary heart disease. Proteins were separated by 2D-electrophoresis, protein fractions were identified by their peptide fingerprint by MALDI method; fractions with more than twofold increase in protein level were determined. In blood serum of patients with coronary atherosclerosis, the content of C4 complement protein increased and ceruloplasmin level decreased, which is typical of heart failure and coronary heart disease.

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