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Sulfur dioxide prodrugs: triggered release of SO 2 via a click reaction.

Wenyi Wang, Xingyue Ji, Zhenming Du, Binghe Wang
Chemical Communications : Chem Comm 2017 January 25
Sulfur dioxide (SO2 ) is being recognized as a possible endogenous gasotransmitter with importance on par with that of NO, CO, and H2 S. Herein we describe a series of SO2 prodrugs that are activated for SO2 release via a bioorthogonal click reaction. The release rate can be tuned by adjusting the substituents on the prodrug.

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