We have located links that may give you full text access.
Case Reports
Journal Article
Combination therapy for fit (younger and older) newly diagnosed multiple myeloma patients: Data support carfilzomib, lenalidomide, and dexamethasone independent of cytogenetic risk status.
Seminars in Oncology 2016 December
In this invited paper, I was asked to critically review available literature and seek scientific and clinical evidence to argue in support of carfilzomib, lenalidomide, and dexamethasone (KRd) as the new default therapy for fit patients with a new diagnosis of multiple myeloma (MM). When performing the review of existing data and when writing this paper it became clear to me that both KRd and bortezomib, lenalidomide, and dexamethasone (RVd) are both recommended by established, well-respected expert guidelines. Importantly, the actual data behind guidelines supporting KRd and RVd come from phase II studies; thus, the level of scientific evidence behind KRd and RVd is the same. When reviewing efficacy and safety data for both regimens, I conclude that published peer-reviewed KRd original data are well in line with modern treatment goals for newly diagnosed MM patients: rapid, deep, and sustainable treatment effect with limited toxicity. Taken together, available scientific and clinical evidence favors KRd as the new default therapy for fit patients with a new diagnosis of MM. Original data support KRd independent of cytogenetic risk status; indeed, patients with standard-risk disease (which represents 75% of all newly diagnosed MM patients) have the strongest benefit of KRd.
Full text links
Related Resources
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app