We have located links that may give you full text access.
Hepatobiliary scintigraphy may improve radioembolization treatment planning in HCC patients.
EJNMMI Research 2017 December
BACKGROUND: Routine work-up for transarterial radioembolization, based on clinical and laboratory parameters, sometimes fails, resulting in severe hepatotoxicity in up to 5% of patients. Quantitative assessment of the pretreatment liver function and its segmental distribution, using hepatobiliary scintigraphy may improve patient selection and treatment planning. A case series will be presented to illustrate the potential of this technique. Hepatocellular carcinoma patients with cirrhosis (Child-Pugh A and B) underwent hepatobiliary scintigraphy pre- and 3 months post-radioembolization as part of a prospective study protocol, which was prematurely terminated because of limited accrual. Included patients were analysed together with their clinical, laboratory and treatment data.
RESULTS: Pretreatment-corrected (99m)Tc-mebrofenin liver uptake rates were marginal (1.8-3.0%/min/m(2)), despite acceptable clinical and laboratory parameters. Posttreatment liver functions seriously declined (corrected (99m)Tc-mebrofenin liver uptake rates: 0.6-2.4%/min/m(2)), resulting in lethal radioembolization-induced liver disease in two out of three patients.
CONCLUSIONS: Hepatobiliary scintigraphy may be of added value during work-up for radioembolization, to estimate liver function reserve and its segmental distribution, especially in patients with underlying cirrhosis, for whom analysis of clinical and laboratory parameters may not be sufficient.
RESULTS: Pretreatment-corrected (99m)Tc-mebrofenin liver uptake rates were marginal (1.8-3.0%/min/m(2)), despite acceptable clinical and laboratory parameters. Posttreatment liver functions seriously declined (corrected (99m)Tc-mebrofenin liver uptake rates: 0.6-2.4%/min/m(2)), resulting in lethal radioembolization-induced liver disease in two out of three patients.
CONCLUSIONS: Hepatobiliary scintigraphy may be of added value during work-up for radioembolization, to estimate liver function reserve and its segmental distribution, especially in patients with underlying cirrhosis, for whom analysis of clinical and laboratory parameters may not be sufficient.
Full text links
Related Resources
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app