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Synthesis and Preliminary Biological Evaluation of Indol-3-yl-oxoacetamides as Potent Cannabinoid Receptor Type 2 Ligands.
A small series of indol-3-yl-oxoacetamides was synthesized starting from the literature known N -(adamantan-1-yl)-2-(5-(furan-2-yl)-1-pentyl-1 H -indol-3-yl)-2-oxoacetamide ( 5 ) by substituting the 1-pentyl-1 H -indole subunit. Our preliminary biological evaluation showed that the fluorinated derivative 8 is a potent and selective CB₂ ligand with K i = 6.2 nM.
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