We have located links that may give you full text access.
[Influence of occupational stress and 5-hydroxytryptamine 2A receptor gene polymorphisms on depression in workers in a thermal power plant].
Chinese Journal of Industrial Hygiene and Occupational Diseases 2016 October 21
Objective: To investigate the association of occupational stress and 5-hydroxytryptamine 2A (5-HT2A) receptor gene polymorphisms with depression. Methods: In November 2010, cluster sampling was used to select 589 workers in a thermal power plant as study subjects. Questionnaires were used to investigate demographic features and occupational stressors. Polymerase chain reaction-restriction fragment length polymorphism was used to detect the genotypes of T102C and A-1438G in 5-HT2A receptor gene in 589 workers. Results: High-level daily hassles ( OR =3.013, 95% CI 1.642~5.530) , more negative emotion ( OR =4.808, 95% CI 2.662~8.681) , more body needs ( OR =1.890, 95% CI 1.034~3.453) , and severe role conflict ( OR =1.815, 95% CI 1.002~3.288) were risk factors for depression, while high rewards ( OR =0.424, 95% CI 0.226~0.796) was the protective factor against depression (all P <0.05). There were no significant differences in T102C genotype and allele distributions between the groups with and without depression ( P >0.05) ; there was a significant difference in A-1438G genotype distribution between the groups with and without depression (χ2 = 9.573, P <0.05) , while there was no significant difference in A-1438G allele distribution between these groups ( P >0.05). The risk of depression in the workers with high-level daily hassles who carried TC genotype ( OR = 4.473, 95% CI 1.161~17.238) or CC genotype ( OR =5.176, 95% CI 1.367~19.593) of T102C was 4.473 and 5.176 times that in those with low-level daily hassles who carried TT genotype, and the risk of depression in the workers with more negative emotions who carried TC genotype ( OR =5.667, 95% CI 1.204~26.673) or CC genotype ( OR =8.114, 95% CI 1.747~37.677) of T102C was 5.667 and 8.114 times that in those with less negative emotion who carried TT genotype. The risk of depression in the workers with high-level daily hassles who carried AG genotype ( OR =4.505, 95% CI 2.215~9.162) or GG genotype ( OR =6.484, 95% CI 2.562~ 16.414) of A-1438G was 4.505 and 6.484 times that in those with low-level daily hassles who carried AA genotype, and the risk of depression in the workers with more negative emotion who carried AG genotype ( OR = 4.877, 95% CI 2.326~10.223) or GG genotype ( OR =9.090, 95% CI 3.491~23.673) of A-1438G was 4.877 and 9.090 times that in those with less negative emotion who carried AA genotype. The risk of depression in the workers with higher rewards who carried AG genotype ( OR =0.152, 95% CI 0.074~0.310) or GG genotype ( OR = 0.384, 95% CI 0.153~0.964) of A-1438G was 0.152 and 0.384 times that in those with lower rewards who carried AA genotype. Conclusion: Occupational stress is associated with the development of depression and interacts with 5-HT2A receptor gene polymorphisms.
Full text links
Related Resources
Trending Papers
Heart failure with preserved ejection fraction: diagnosis, risk assessment, and treatment.Clinical Research in Cardiology : Official Journal of the German Cardiac Society 2024 April 12
Proximal versus distal diuretics in congestive heart failure.Nephrology, Dialysis, Transplantation 2024 Februrary 30
Efficacy and safety of pharmacotherapy in chronic insomnia: A review of clinical guidelines and case reports.Mental Health Clinician 2023 October
World Health Organization and International Consensus Classification of eosinophilic disorders: 2024 update on diagnosis, risk stratification, and management.American Journal of Hematology 2024 March 30
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app