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JOURNAL ARTICLE
RESEARCH SUPPORT, NON-U.S. GOV'T
Polycycloiridals with a Cyclopentane Ring from Iris tectorum.
Journal of Natural Products 2017 January 28
Six new iridal-type triterpenoids containing an unprecedented cyclopentane ring, polycycloiridals E-J (1-6), were isolated from a large-scale re-extraction of Iris tectorum. A possible biosynthesis pathway is postulated. The known spirioiridotectal D (7) was also obtained in the current investigation, and its structure was unequivocally defined using X-ray diffraction data. Compound 7 suppressed LPS-activated NO production in the BV2 cell line with an IC50 value of 0.54 μM.
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