JOURNAL ARTICLE
RESEARCH SUPPORT, NON-U.S. GOV'T
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FUEL-mLoc: feature-unified prediction and explanation of multi-localization of cellular proteins in multiple organisms.

Bioinformatics 2017 March 2
Although many web-servers for predicting protein subcellular localization have been developed, they often have the following drawbacks: (i) lack of interpretability or interpreting results with heterogenous information which may confuse users; (ii) ignoring multi-location proteins and (iii) only focusing on specific organism. To tackle these problems, we present an interpretable and efficient web-server, namely FUEL-mLoc, using eature- nified prediction and xplanation of m ulti- oc alization of cellular proteins in multiple organisms. Compared to conventional localization predictors, FUEL-mLoc has the following advantages: (i) using unified features (i.e. essential GO terms) to interpret why a prediction is made; (ii) being capable of predicting both single- and multi-location proteins and (iii) being able to handle proteins of multiple organisms, including Eukaryota, Homo sapiens, Viridiplantae, Gram-positive Bacteria, Gram-negative Bacteria and Virus . Experimental results demonstrate that FUEL-mLoc outperforms state-of-the-art subcellular-localization predictors.

Availability and Implementation: https://bioinfo.eie.polyu.edu.hk/FUEL-mLoc/.

Contacts: [email protected] or [email protected].

Supplementary information: Supplementary data are available at Bioinformatics online.

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