INDICATORS OF PHAGOCYTIC COMPONENT AND SECRETORY IGA IN CHILDREN WITH BRONCHIAL ASTHMA SECONDARY TO UNDIFFERENTIATED CONNECTIVE TISSUE DYSPLASIA.

Its aim is to improve the diagnostics and treatment of Bronchial Asthma. There were examined 93 children with bronchial asthma at the age of 6-10 years. All patients were diagnosed with partially controlled or uncontrolled clinical course of bronchial asthma and manifestations of undifferentiated connective tissue dysplasia. The control group included 21 practically healthy children of the same age. The diagnosis of bronchial asthma was made, and the clinical course was determined in accordance with the criteria approved by the Order of Ministry of Health of Ukraine of October 08, 2013 No 868 "Unified clinical protocol of primary, secondary (specialized) medical care "Bronchial Asthma in Children" and GINA criteria (updated in 2015). The manifestations of undifferentiated connective tissue dysplasia were diagnosed according to the major and minor criteria of screening diagnostics using the methods ofMiolkovska-Dmitrova T, Karkashov A (1985). The study has revealed the negative impacts of environmental factors and pathological course of pregnancy on the development of bronchial asthma and undifferentiated connective tissue dysplasia. Infectious diseases, acute respiratory viral infection and pneumonia in particular, often triggered the first asthma symptoms in examined children. The direct correlation between the level of the lack of asthma control and undifferentiated connective tissue dysplasia (rφ=0.54; р<0.001) has been proven. In children with bronchial asthma secondary to undifferentiated connective tissue dysplasia the level of sIgA in saliva decreased significantly compared to the control group: 110.23±5.37 versus 149.71±2.23 mg/l, respectively (р<0.01). The direct correlation between the indicators of phagocytosis and secretory IgA (rs=0.29-0.41, р<0.05) has been proven.