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Research Support, Non-U.S. Gov't
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Too Much of a Good Thing? Chronic IFN Fuels Resistance to Cancer Immunotherapy.

James L Reading, Sergio A Quezada
Immunity 2016 December 21
Immune checkpoint blockade (ICB) is revolutionizing cancer medicine, yet the molecular basis of resistance remains unclear. In a recent issue of Cell, Benci et al. (2016) demonstrate that sustained interferon signaling is central to the development of PD-L1-dependent and -independent resistance to ICB.

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