Serine Metabolism Links Tumor Suppression to the Epigenetic Landscape.

Intermediary metabolism provides substrates that shape epigenetic status, but whether this interaction can be responsible for oncogenesis is largely unknown. In a recent issue of Nature, Kottakis et al. (2016) now show that the common tumor suppressor gene LKB1 can function by mediating this connection through an LKB1/AMPK/mTOR signaling axis.