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Aminoglycoside-based novel probes for bacterial diagnostic and therapeutic applications.
Chemical Communications : Chem Comm 2017 January 25
Specific detection of pathogens has long been recognized as a vital strategy in the control of infectious diseases. Two novel theranostic neomycin analogs exhibit efficient targeting, labelling and killing of broad spectrum bacteria while not damaging macrophage-like cells. Furthermore, lipidated probe 2 clearly showed antibacterial activity against methicillin-resistant S. aureus.
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