We have located links that may give you full text access.
JOURNAL ARTICLE
RESEARCH SUPPORT, NON-U.S. GOV'T
Visualization of Stepwise Drug-Micelle Aggregate Formation and Correlation with Spectroscopic and Calorimetric Results.
Journal of Physical Chemistry. B 2016 November 18
Palmatine and berberine, imperative isoquinoline alkaloids, have many potential therapeutic uses. We visualized the stepwise complex formation between these alkaloids and sodium dodecyl sulfate (SDS), a known anionic surfactant characterizing alkaloid-induced SDS micelle formation at different stages. UV-visible spectra directly divulged the complex formation at different stages, and this was supported by the fluorescence emission spectral and fluorescence anisotropy data. Fluorescence quenching experiments precisely located the alkaloid molecules in the micellar environment above the critical micelle concentration (CMC). The thermodynamics of the alkaloid binding and micelle formation suggested an exothermic enthalpy-driven initial electrostatic binding followed by an endothermic entropy-driven binding in the micellar core, both being spontaneous in nature. The atomic force microscopy results clearly visualized the shape and size of the alkaloid-induced micelles. This study presents stepwise characterization of alkaloid-SDS interaction below and above the CMC.
Full text links
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app