Association between IL-27 gene polymorphisms and risk of papillary thyroid carcinoma.

Xinwen Nie, Fang Yuan, Peng Chen, Yan Pu, Jingqiang Zhu, Yichao Wang, Xue Xiao, Guanglu Che, Linbo Gao, Lin Zhang

Biomarkers in Medicine 2017 Februrary

AIM: IL-27 has potent antitumor effects. We aimed to examine the contribution of single nucleotide polymorphisms in IL-27 to the risk of papillary thyroid carcinoma (PTC).

MATERIALS & METHODS: IL-27 rs153109 and rs17855750 were analyzed in 496 PTC patients and 629 controls, using a polymerase chain reaction-restriction fragment length polymorphism method.

RESULTS: The rs153109 AG and AG/GG genotypes were significantly associated with increased risks for PTC. Significantly increased PTC risk was also associated with rs17855750 GT and GT/GG genotypes. Combined genotypes of rs153109 AG/GG and rs17855750 GT/GG increased the risk of PTC (p < 0.05).

CONCLUSION: These findings showed that IL-27 rs153109 and rs17855750 might be related to the tumorigenesis of PTC.

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