JOURNAL ARTICLE
REVIEW
Add like
Add dislike
Add to saved papers

Review of imaging network activities in developing rodent cerebral cortex in vivo.

Neurophotonics 2017 July
The combination of voltage-sensitive dye imaging (VSDI) with multielectrode array (MEA) recordings in the rodent cerebral cortex in vivo allows the simultaneous analysis of large-scale network interactions and electrophysiological single-unit recordings. Using this approach, distinct patterns of spontaneous and sensory-evoked activity can be recorded in the primary somatosensory (S1) and motor cortex (M1) of newborn rats. Already at the day of birth, gamma oscillations and spindle bursts in the barrel cortex synchronize the activity of a local columnar ensemble, thereby generating an early topographic representation of the sensory periphery. During the first postnatal week, both cortical activity patterns undergo developmental changes in their spatiotemporal properties and spread into neighboring cortical columns. Simultaneous VSDI and MEA recordings in S1 and M1 demonstrate that the immature motor cortex receives information from the somatosensory system and that M1 may trigger movements of the periphery, which subsequently evoke gamma oscillations and spindle bursts in S1. These early activity patterns not only play an important role in the development of the cortical columnar architecture, they also control the ratio of surviving versus dying neurons in an activity-dependent manner, making these processes most vulnerable to pathophysiological disturbances during early developmental stages.

Full text links

We have located links that may give you full text access.
Can't access the paper?
Try logging in through your university/institutional subscription. For a smoother one-click institutional access experience, please use our mobile app.

For the best experience, use the Read mobile app

Mobile app image

Get seemless 1-tap access through your institution/university

For the best experience, use the Read mobile app

All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.

By using this service, you agree to our terms of use and privacy policy.

Your Privacy Choices Toggle icon

You can now claim free CME credits for this literature searchClaim now

Get seemless 1-tap access through your institution/university

For the best experience, use the Read mobile app