Targeting Immune Suppression in Cancer.

Researchers have figured out a way to switch the immunosuppressive phenotype of tumor-associated macrophages to one that's immunostimulatory. By inhibiting PI3Kγ in these macrophages, they significantly suppressed tumor growth in mice; when anti-PD-1 therapy was added to PI3Kγ inhibition, complete and sustained tumor eradication was observed in many cases.