JOURNAL ARTICLE
RESEARCH SUPPORT, NON-U.S. GOV'T
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Increased Telomerase Reverse Transcriptase Expression Associates with Spontaneous Exit from M-II Arrest in Rat Eggs.

Cellular Reprogramming 2017 Februrary
In mammals, postovulatory egg aging deteriorates egg quality possibly by mediating spontaneous exit from metaphase-II (M-II) arrest and/or inducing apoptosis. To test this possibility, present study was designed to investigate telomerase reverse transcriptase (TERT) expression, Bcl2 expression, and DNA fragmentation during postovulatory egg aging in vivo, as well as in vitro. Results suggest that postovulatory egg aging induced a time-dependent increase in the number of eggs undergoing spontaneous exit from M-II arrest in vivo, as well as in vitro. However, rate of spontaneous exit from M-II arrest was high in eggs cultured in vitro compared to in vivo aging. A time-dependent increase of TERT expression was associated with postovulatory aging-mediated spontaneous exit from M-II arrest in vivo, as well as in vitro. The Bcl2 level did not reduce and DNA fragmentation was not detected until 7 hours of in vivo, as well as in vitro, postovulatory egg aging. Taken together these data suggest that the eggs undergo postovulatory aging as evidenced by increased TERT expression without having any decrease of Bcl2 level or increase of DNA fragmentation until 7 hours of in vivo, as well as in vitro egg aging.

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