Approach to osteomyelitis treatment with antibiotic loaded PMMA.

Zhang Wentao, Guangyu Lei, Yang Liu, Wei Wang, Tao Song, Jinzhu Fan

Microbial Pathogenesis 2017 January

BACKGROUND: To reduce the incidence of osteomyelitis infection, local antibiotic impregnated delivery systems are commonly used as a promising and effective approach to deliver high antibiotic concentrations at the infection site.

OBJECTIVE: The objective of this review was to provide a literature review regarding approach to osteomyelitis treatment with antibiotic loaded PMMA.

STUDY DESIGN: Literature study regarding osteomyelitis treatment with antibiotic loaded carriers using key terms Antibiotic, osteomyelitis, biodegradable PMMA through published articles. Hands searching of bibliographies of identified articles were also undertaken.

CONCLUSION: We concluded that Antibiotic-impregnated PMMA beads are useful options for the treatment of osteomyelitis for prolonged drug therapy.

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