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JOURNAL ARTICLE
REVIEW
Melanocytic Nevi and the Genetic and Epigenetic Control of Oncogene-Induced Senescence.
Dermatologic Clinics 2017 January
Melanocytic nevi represent benign clonal proliferations of the melanocytes in the skin that usually remain stable in size and behavior or disappear during life. Infrequently, melanocytic nevi undergo malignant transformation to melanoma. Understanding molecular and cellular mechanisms underlying oncogene-induced senescence should help identify pathways underlying melanoma development, leading to the development of new strategies for melanoma prevention and early detection.
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