We have located links that may give you full text access.
Decreased plasma concentrations of brain-derived neurotrophic factor in preeclampsia.
BACKGROUND: Preeclampsia (PE) is a disease characterized by excessive maternal inflammatory response. Early studies suggested that brain-derived neurotrophic factor (BDNF) modulates inflammation. The main objective of this study was to investigate BDNF plasma concentrations in PE women and to compare with BDNF concentrations from normotensive pregnant women. We also investigated the association among the plasma concentrations of BDNF and inflammatory mediators, and maternal clinical features.
METHODS: BDNF plasma concentrations were measured by ELISA in 38 PE women (17 early onset and 21 late onset) and in 20 normotensive pregnant women (Norm) matched for gestational age (Norm<34weeks: n=8; Norm≥34weeks: n=12). Correlation analyses between laboratory parameters and clinical characteristics were evaluated through Spearman's coefficients.
RESULTS: BDNF concentration was lower in PE women than in normotensive pregnant women, but no difference was detected between the subgroups of PE women and normotensive pregnant women. BDNF correlated negatively with annexin A1, and positively with body mass index and diastolic blood pressure. No correlation was significant in normotensive pregnant women.
CONCLUSIONS: Lower BDNF plasma concentrations and cross-talk between BDNF and AnxA1 signaling pathways might be involved in PE pathogenesis.
METHODS: BDNF plasma concentrations were measured by ELISA in 38 PE women (17 early onset and 21 late onset) and in 20 normotensive pregnant women (Norm) matched for gestational age (Norm<34weeks: n=8; Norm≥34weeks: n=12). Correlation analyses between laboratory parameters and clinical characteristics were evaluated through Spearman's coefficients.
RESULTS: BDNF concentration was lower in PE women than in normotensive pregnant women, but no difference was detected between the subgroups of PE women and normotensive pregnant women. BDNF correlated negatively with annexin A1, and positively with body mass index and diastolic blood pressure. No correlation was significant in normotensive pregnant women.
CONCLUSIONS: Lower BDNF plasma concentrations and cross-talk between BDNF and AnxA1 signaling pathways might be involved in PE pathogenesis.
Full text links
Related Resources
Trending Papers
Challenges in Septic Shock: From New Hemodynamics to Blood Purification Therapies.Journal of Personalized Medicine 2024 Februrary 4
Molecular Targets of Novel Therapeutics for Diabetic Kidney Disease: A New Era of Nephroprotection.International Journal of Molecular Sciences 2024 April 4
The 'Ten Commandments' for the 2023 European Society of Cardiology guidelines for the management of endocarditis.European Heart Journal 2024 April 18
A Guide to the Use of Vasopressors and Inotropes for Patients in Shock.Journal of Intensive Care Medicine 2024 April 14
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app