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Atopic Dermatitis According to GARP: New Mechanistic Insights in Disease Pathogenesis.

Janna Nousbeck, Alan D Irvine
Journal of Investigative Dermatology 2016 December
In complex disease such as atopic dermatitis, the journey from identification of strong risk loci to profound functional and mechanistic insights can take several years. Here, Manz et al. have elegantly deciphered the mechanistic pathways in the well-established 11q13.5 atopic dermatitis risk locus. Their genetic and functional insights emphasize a role for T regulatory cells in atopic dermatitis pathogenesis.

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