We have located links that may give you full text access.
Journal Article
Research Support, Non-U.S. Gov't
Meta-adaptation in the auditory midbrain under cortical influence.
Nature Communications 2016 November 25
Neural adaptation is central to sensation. Neurons in auditory midbrain, for example, rapidly adapt their firing rates to enhance coding precision of common sound intensities. However, it remains unknown whether this adaptation is fixed, or dynamic and dependent on experience. Here, using guinea pigs as animal models, we report that adaptation accelerates when an environment is re-encountered-in response to a sound environment that repeatedly switches between quiet and loud, midbrain neurons accrue experience to find an efficient code more rapidly. This phenomenon, which we term meta-adaptation, suggests a top-down influence on the midbrain. To test this, we inactivate auditory cortex and find acceleration of adaptation with experience is attenuated, indicating a role for cortex-and its little-understood projections to the midbrain-in modulating meta-adaptation. Given the prevalence of adaptation across organisms and senses, meta-adaptation might be similarly common, with extensive implications for understanding how neurons encode the rapidly changing environments of the real world.
Full text links
Related Resources
Trending Papers
Challenges in Septic Shock: From New Hemodynamics to Blood Purification Therapies.Journal of Personalized Medicine 2024 Februrary 4
Molecular Targets of Novel Therapeutics for Diabetic Kidney Disease: A New Era of Nephroprotection.International Journal of Molecular Sciences 2024 April 4
The 'Ten Commandments' for the 2023 European Society of Cardiology guidelines for the management of endocarditis.European Heart Journal 2024 April 18
A Guide to the Use of Vasopressors and Inotropes for Patients in Shock.Journal of Intensive Care Medicine 2024 April 14
Diagnosis and Management of Cardiac Sarcoidosis: A Scientific Statement From the American Heart Association.Circulation 2024 April 19
Essential thrombocythaemia: A contemporary approach with new drugs on the horizon.British Journal of Haematology 2024 April 9
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app