We have located links that may give you full text access.
Global gain modulation generates time-dependent urgency during perceptual choice in humans.
Nature Communications 2016 November 25
Decision-makers must often balance the desire to accumulate information with the costs of protracted deliberation. Optimal, reward-maximizing decision-making can require dynamic adjustment of this speed/accuracy trade-off over the course of a single decision. However, it is unclear whether humans are capable of such time-dependent adjustments. Here, we identify several signatures of time-dependency in human perceptual decision-making and highlight their possible neural source. Behavioural and model-based analyses reveal that subjects respond to deadline-induced speed pressure by lowering their criterion on accumulated perceptual evidence as the deadline approaches. In the brain, this effect is reflected in evidence-independent urgency that pushes decision-related motor preparation signals closer to a fixed threshold. Moreover, we show that global modulation of neural gain, as indexed by task-related fluctuations in pupil diameter, is a plausible biophysical mechanism for the generation of this urgency. These findings establish context-sensitive time-dependency as a critical feature of human decision-making.
Full text links
Related Resources
Trending Papers
Challenges in Septic Shock: From New Hemodynamics to Blood Purification Therapies.Journal of Personalized Medicine 2024 Februrary 4
Molecular Targets of Novel Therapeutics for Diabetic Kidney Disease: A New Era of Nephroprotection.International Journal of Molecular Sciences 2024 April 4
The 'Ten Commandments' for the 2023 European Society of Cardiology guidelines for the management of endocarditis.European Heart Journal 2024 April 18
A Guide to the Use of Vasopressors and Inotropes for Patients in Shock.Journal of Intensive Care Medicine 2024 April 14
Diagnosis and Management of Cardiac Sarcoidosis: A Scientific Statement From the American Heart Association.Circulation 2024 April 19
Essential thrombocythaemia: A contemporary approach with new drugs on the horizon.British Journal of Haematology 2024 April 9
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app