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JOURNAL ARTICLE
Redox Paradox: Can Hypoxia Heal Ischemic Hearts?
Developmental Cell 2016 November 22
Adult cardiomyocytes are largely thought to lack proliferative and therefore regenerative potential. Reporting in Nature, Nakada et al. (2016) find that a hypoxic regime reduces mitochondrial metabolism and promotes proliferation in adult mouse cardiomyocytes, resulting in increased regeneration following myocardial infarction. These findings suggest the potential to transform post-MI care.
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