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Eukaryotic Ribosome as a Target for Cardiovascular Disease.

Simone Pellegrino, Gulnara Yusupova
Cell Chemical Biology 2016 November 18
Cardiovascular diseases have been associated with genetic variants and increased plasma level of the secreted protein PCSK9. In this issue of Cell Chemical Biology, Petersen et al. (2016) describe an inhibitor of PCSK9 secretion in human cells that, surprisingly, targets the 80S ribosome.

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