We have located links that may give you full text access.
Cervical compressive myelopathy: flow analysis of cerebrospinal fluid using phase-contrast magnetic resonance imaging.
European Spine Journal 2017 January
PURPOSE: To evaluate cerebrospinal fluid (CSF) flow in cervical compressive myelopathy (CCM), by both quantitative and qualitative analyses, using 3T cine phase-contrast magnetic resonance imaging (cine MRI).
METHODS: From September, 2014 to June, 2015, we enrolled 45 subjects (18 women and 27 men, mean age, 61.7 ± 13.4 years) to undergo cervical cine MRI. The subjects were divided into three groups: no stenosis and cervical stenosis with and without intramedullary T2 hyperintensity. We measured maximal CSF velocity, and 12 CSF velocity waveforms were plotted per subject. Two readers independently assessed the CSF waveform shape (0 absent; 1 serrated; 2 bi-directional with small amplitude; and 3 normal bi-directional waveform) and the CSF motion pattern (0 absent; 1 interrupted; and 2 intact). The numbers of 12 waveform shapes were summed to yield a CSF waveform score. Linear mixed model and ROC curve analyses were used for statistical analyses.
RESULTS: Maximal CSF velocity was significantly lower in CCM (marginal mean, 2.72 cm/s) than in stenosis without intramedullary T2 hyperintensity (3.27 cm/s, p = 0.027) and no stenosis (3.80 cm/s, p < 0.001). Bi-phasic CSF motion was lost in cervical stenosis. CSF waveform scores of 17 (area under curve (AUC), 0.797; p = 0.003) and 16.5 (AUC, 0.790; p = 0.004) could predict Japanese Orthopedic Association (JOA) score corresponding to CCM.
CONCLUSIONS: Maximal CSF velocity and CSF waveform score on cine MRI decreased in CCM and was correlated with the JOA score. Thus, both quantitative and qualitative analyses using cine MRI could effectively demonstrate CSF flow alterations in CCM.
METHODS: From September, 2014 to June, 2015, we enrolled 45 subjects (18 women and 27 men, mean age, 61.7 ± 13.4 years) to undergo cervical cine MRI. The subjects were divided into three groups: no stenosis and cervical stenosis with and without intramedullary T2 hyperintensity. We measured maximal CSF velocity, and 12 CSF velocity waveforms were plotted per subject. Two readers independently assessed the CSF waveform shape (0 absent; 1 serrated; 2 bi-directional with small amplitude; and 3 normal bi-directional waveform) and the CSF motion pattern (0 absent; 1 interrupted; and 2 intact). The numbers of 12 waveform shapes were summed to yield a CSF waveform score. Linear mixed model and ROC curve analyses were used for statistical analyses.
RESULTS: Maximal CSF velocity was significantly lower in CCM (marginal mean, 2.72 cm/s) than in stenosis without intramedullary T2 hyperintensity (3.27 cm/s, p = 0.027) and no stenosis (3.80 cm/s, p < 0.001). Bi-phasic CSF motion was lost in cervical stenosis. CSF waveform scores of 17 (area under curve (AUC), 0.797; p = 0.003) and 16.5 (AUC, 0.790; p = 0.004) could predict Japanese Orthopedic Association (JOA) score corresponding to CCM.
CONCLUSIONS: Maximal CSF velocity and CSF waveform score on cine MRI decreased in CCM and was correlated with the JOA score. Thus, both quantitative and qualitative analyses using cine MRI could effectively demonstrate CSF flow alterations in CCM.
Full text links
Related Resources
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app
All material on this website is protected by copyright, Copyright © 1994-2024 by WebMD LLC.
This website also contains material copyrighted by 3rd parties.
By using this service, you agree to our terms of use and privacy policy.
Your Privacy Choices
You can now claim free CME credits for this literature searchClaim now
Get seemless 1-tap access through your institution/university
For the best experience, use the Read mobile app